Suspense creator. health tips
Feb 15, 2021
Green tea • Protein • Drink • DNA repair •
There are many types of cancer and health issues like lung cancer, prostate cancer high blood pressure, bad cholesterol, and many more, and the medical advice for Treating cancer is few less. Now let’s talk about who green tea can fight against it.
Green tea can help contribute to a healthy body in a number of ways. Prior studies show a daily cup may improve brain function and even fighting obesity. Now scientists say the traditional Chinese drink could hold the key to beating cancer.
According to researchers at the Rensselaer Polytechnic Institute, green tea may switch on a gene called p53, which blocks the development of tumors. The protein destroys damaged cells or stops them from dividing as repairs are carried out. It is mutated or inactivated in most types of cancer. An antioxidant found in green tea, however, improves its efficiency, the study shows.
Study authors say their finding offers hope of a drug that mimics epigallocatechin gallate, or EGCG, the main active compound. Professor Chen Pei, the study’s senior author, and an engineering professor says his team plans to do more research with green tea and explore potential cancer treatments.
How p53 is cancer kryptonite (The Super Man)
Wang considers p53 as “arguably the most important protein in human cancer.” The natural cancer-fighting protein was hailed the “guardian of the genome” after its discovery in 1979. One end, known as the “N-terminal domain,” has a flexible shape, enabling it to serve several functions. But as Wang and colleagues explain in the latest issue of Cell, two specific mutations in the protein – which alters how its cysteine amino acid residues fold and interact with each other – can lead to tumor formation.
Many of these mutant forms of p53, which are called PARP1-discovered in 2008, are naturally occurring and usually have a minor negative impact on the cells that make them. This makes them valuable in studying mutations that cause cancer, Wang explains. But mutations in p53 that occur in cancer cells are often detrimental to their health.
In the new study, researchers found that an uncommon form of PARP1, known as p53CL1-derived, or PC1, drives tumor formation. PC1 is made by a cancer-associated gene called Prostate Proliferator-associated apoptosis (ProAP). The team found that increasing levels of PARP1 by reducing the level of ProAP or inducing mutant p53CL1 led to more aggressive tumors.
Because PC1 was a better tumor-promoting agent than PARP1 alone, Wang and colleagues concluded that PARP1 in conjunction with ProAP drives the growth of tumor cells.
That’s an interesting result, but Wang cautions that the findings should be confirmed in human clinical trials
Green tea could unlock the new anti-cancer drug
by JOYDEB NANDI
The study raises hopes for a new generation of anti-cancer drugs that work by boosting p53 activity. It controls the cell cycle. When functioning properly, it activates DNA repair mechanisms and prevents cells with damaged DNA from dividing. If DNA damage is irreparable, p53 induces the cell to destroy itself by undergoing apoptosis, or programmed cell death. When p53 is turned off by mutation or deletion, cells are much more likely to become cancerous, because they will divide uncontrollably even when DNA is damaged.
Since it is commonly switched off in human cancers, reactivating it could potentially provide a powerful way of treating the disease in the future.
The findings also shed fresh light on the benefits of green tea. It has been shown to help prevent a host of diseases including cancer, heart disease, and diabetes – and halve the risk of dementia. A study of over 100,000 older Chinese people found those who drank at least three cups of green tea a week were 25 percent less likely to die over the next seven years.
Following this line of research, the team will be working to identify the specific compound responsible for activating p53 and find ways to boost its activity. They also plan to carry out more studies to better understand how the compound works and in turn how it could be harnessed to target cancerous cells.
Making Healthy Green Tea at Home
Making green tea is very simple. Just follow the tips
Boil the drinking water and allow to cool slightly for 2-3 mins, this slightly cooler water will get the best out of your delicate tea leaves.
Pour the water onto the tea bag to release its delicious aroma.
Leave the tea bag to infuse for up to 3 minutes. If you like a stronger taste you can brew a little longer but watch out, over brewing can cause bitterness.
Remove the tea bag and enjoy your deliciously refreshing Lipton Green Tea!
Top tip: allow to cool and add ice to enjoy a DIY Lipton Iced Green Tea on a hot day!
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